Revista Brasileira de Ginecologia e Obstetrícia

Spontaneous rupture of renal angiomyolipoma during pregnancy

DOI: 10.1590/SO100-720320140005019 - volume 36 - Agosto 2014

Mariana Mouraz Lopes dos Santos, Sara Marques Soares Proença, Maria Inês Nunes Pereira de Almeida Reis, Rui Miguel Almeida Lopes Viana, Luísa Maria Bernardo Martins, João Manuel dos Reis Colaço, Filomena Maria Pinheiro Nunes

Abstract

Renal angiomyolipoma is a benign tumor, composed of adipocytes, smooth muscle cells and blood vessels. The association with pregnancy is rare and related with an increased risk of complications, including rupture with massive retroperitoneal hemorrhage. The follow-up is controversial because of the lack of known cases, but the priorities are: timely diagnosis in urgent cases and a conservative treatment when possible. The mode of delivery is not consensual and should be individualized to each case. We report a case of a pregnant woman with 18 weeks of gestation admitted in the emergency room with an acute right low back pain with no other symptoms. The diagnosis of rupture of renal angiomyolipoma was established by ultrasound and, due to hemodinamically stability, conservative treatment with imaging and clinical monitoring was chosen. At 35 weeks of gestation, it was performed elective cesarean section without complications for both mother and fetus.

Full Text

Introduction

The angiomyolipoma (AML) is often a benign tumor consisting of three types of histologic features: adipocytes, smooth muscle cells and blood vessels with thickened wall1 - 3. The incidence of renal AML is 0.3% in the general population and represents 3% of solid renal masses1 - 4, being even more infrequent during pregnancy1 , 4 - 6. There are two known types of AML: the isolated angiomyolipoma, which represents 80% of cases, and the one associated with tuberous sclerosis (TS)1 , 7 , 8. In the first case, these masses are usually solitary, large and asymptomatic, and the mean age of diagnosis is 43 years1 , 4 , 7. When associated with TS are often multiple, bilateral and small, and hemorrhage is frequent8. The diagnosis is made at earlier ages, 20-30 years1 , 2 , 8. As in most cases there are no symptomatic manifestations1 , 2, the AMLs are often diagnosed as incidentalomas1 , 4, however they may be related to severe symptoms9 - 12.

The risk of spontaneous rupture associated with pregnancy is higher and can be catastrophic5 , 7. A conservative approach, with preservation of renal function by selective embolization or partial nephrectomy, is possible and preferable in most patients2 , 4 , 5 , 13.

Case report

TM, 40 years old, gesta 3, para 2, current pregnancy through in vitro fertilization, had two transverse segmental cesarean sections in 2000 and 2003. Patient had no relevant family history.

The pregnancy proceeded without complications until 18 weeks of gestation, when appeared a low back pain radiating to right upper abdominal quadrant, with no other associated symptoms. On physical and analytical examination, it was found a positive renal Murphy sign, microscopic hematuria, hemoglobin of 10.8 mg/dL and 5.82 mg/dL of C-reactive protein. In the ultrasound, a 5 cm nodular lesion in the right kidney was detected, what suggests anhyperechoic, heterogeneous AML, consistent with probable hemorrhage (Figure 1). The patient underwent only conservative measures, and the bleeding stopped spontaneously. Two months after the first ultrasound, a magnetic resonance imaging (MRI) was performed and there was no evidence of increasing (Figure 2). Regularity of the pain, which was frequent and progressively worsening, breech presentation and two previous cesarean-scars led to schedule a cesarean section for 35 weeks. The surgery was performed without any complications. Surgeons opted for a non exhaustive exploration of the retroperitoneal space due to the risk of rupture associated with handling. The 1- and 5-minute ApgarApgar was 9 and 10, respectively, and the immediate post-partum period went linear. The patient refused any surgical treatment and imaging follow-up postpartum.

 

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Figure 1
Renal ultrasound, nodular lesion with 5 cm suggestive of angiomyolipoma

Figure 2
Abdominal magnetic resonance imaging, nodular lesion with 5 cm with hemorrhagic material and subcapsular hematoma

Discussion

The AMLs are uncommon tumors14 , 15. They were first described in 1951 by Morgan et al.3 , 7 , 14. Most of these tumors appear in the kidney (renal parenchyma), however these can be found in other locations, such as the spleen, liver, uterus and fallopian tubes14.

About 20% of the cases are associated with tuberous sclerosis, which is an autosomal dominant disease, rare, characterized by the growth of benign tumors in multiple organs (kidney, brain, heart, lungs and skin)16 - 18. Signs and symptoms depend on the affected organ and may have multiple levels of severity19. AMLs occur in 80% of the patients with TS4 , 8 , 14 , 18 - 21. The majority of the cases occur at earlier ages, present bilateral distribution, are usually multiple, small (<2 cm), benign and asymptomatic4 , 7 , 14. These tend to grow faster when compared to the isolated type and often require earlier surgical treatment3 , 4 , 7 , 14. In cases that arise isolated, the tumor is usually single, unilateral, asymptomatic, appears later in life4 , 14, grows slowly and has better outcomes7.

These tumors are usually asymptomatic, but can manifest as a flank pain, palpable abdominal mass, hematuria, nausea and vomiting1 , 3 , 14 , 20. In 10% of the cases, they manifest as hypovolemic shock resulting from massive retroperitoneal bleeding, known as Wunderlich syndrome1 - 3 , 14 , 21 - 23. The risk factors associated with the spontaneous rupture and perirenal or intratumoral bleeding, include: association with TS, signs and symptoms, a bigger size (> 4 cm) and pregnancy14. The main causes in pregnancy are increased growth rate, blood volume and renal blood flow4 , 14 , 20. The greater growth during pregnancy, the predominance in women in childbearing age and the rarity before puberty suggest clear hormone dependence4 , 5 , 14 , 20.

Ultrasonographically, the tumor presents a hyperechoic mass with great vascularity - existence of arteriovenous shunts (turbulent pulsating flows)14. Computed tomography (CT) is the gold standard exam because it detects fat in the tumor7- highly suggestive of AML3 , 11. MRI can also differentiate fat by its high signal intensity and is a complementary exam currently used when CT is contraindicated and when lesions are small or complex14 , 16.

The main differential diagnosis must be established with renal cell carcinoma14. Other causes of retroperitoneal bleeding are: spontaneous rupture of kidney with hidronefrosis, spontaneous rupture of aneurysm or renal vessels and other vascular accidents9 , 14 , 20.

The follow-up of these patients is highly controversial and debatable due to the lack of known cases1 , 4 , 14; however, in most situations, it is used an algorithm proposed by Oesterling, based on clinical, bilaterally and tumor size4 , 14. Asymptomatic tumors should be controlled with ultrasound or CT every six months if they are greater than 4 cm and once a year if they are smaller1 , 4 , 9 , 14. In symptomatic cases or with bilateral lesions, the choice should be selective arterial embolization or conservative renal surgery (lumpectomy or partial nephrectomy)1 , 4 , 14 , 21 , 24 - 27. Radical nephrectomy is performed in cases of urgency, with uncontrollable bleeding and hemodynamic instability, large tumor size, central location or coexisting carcinoma1 , 14 , 25. The rupture during pregnancy, in many instances, requires an urgent laparotomy in order to control bleeding, by nephrectomy14. Some authors recommend fetal extraction by cesarean section in the same surgical procedure in pregnancies at 28 gestational weeks or more14.

In our case, due to the hemodynamic stability and spontaneous cessation of bleeding it was decided to perform an expectant procedure, even though the tumor size was greater than 4 cm.

As we have seen, it appears that these tumors have a higher growth rate in pregnancy, and the question that often arises is about the best time to perform surgery1 , 4. If there is an absolute necessity to perform surgery, the second trimester of pregnancy is chosen for the following reasons: surgery during the first trimester may increase the rate of abortions and fetal malformations, and in the third trimester there are more technical difficulties and the risk of pre-term delivery increases1 , 4 , 14.

The delivery mode should be discussed case by case, depending on the coexistence of the associated factors14 , 28. Although it seemed that the variations in blood pressure during labor and Valsalva maneuvers could increase the risk of potentially fatal bleeding, there are no evidences that prove a higher incidence of bleeding during a vaginal delivery when compared to the cesarean procedure14.

In conclusion, we have to individualize each case, but always keep in mind the priorities: on-time diagnosis in urgent cases and the most conservative treatment as possible.


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